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Ref 1. Merry et al (2010). “Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial” British Journal of Anaesthesia 104(1): 80-88. Result achieved in a trial of post-operative pain relief after removal of 1-4 wisdom teeth using 2 tablets MAXIGESIC^® compared with paracetamol 1000mg or ibuprofen 300mg alone 4 times a day (paracetamol 4000mg or ibuprofen 1200mg per day). Results assessed on the Intention-to-treat (ITT) patient population, including data following the use of rescue medication. Research sponsored by AFT Pharmaceuticals.

Ref 1.Ref 2. Daniels et al (2018). “Analgesic Efficacy of an Acetaminophen/ibuprofen Fixed- dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial”, Clinical Therapeutics 40 (10): 1765-1776. Result achieved in a trial of post-operative pain relief after removal of at least 2 wisdom teeth using MAXIGESIC^® (paracetamol 975mg/ibuprofen 292.5mg) compared with paracetamol 975mg or ibuprofen 292.5mg alone 4 times a day (paracetamol 3900mg or ibuprofen 1170mg per day). Study results assessed on the intent-to-treat (ITT) population with adjustment for the use of rescue medication. MAXIGESIC^® 975/292.5mg US combination is bioequivalent in fed/non-fasting conditions to MAXIGESIC^® 1000/300mg NZ combination at full dose (Aitken et al., J Bioequiv Availab 2018, 10:5). Research sponsored by AFT Pharmaceuticals.

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